Boosting synthesis of Coenzyme A by administering (L-Pantothenic acid+L-Cysteine), or Pantethine, will cure acne or make any complicated acne more readily cured through the traditional therapies, like antibiotics for infected heads, exfoliating treatment, remedies ...etc.

Acne does not necessarily occur to every individual, if any one who develops the first pimple or white or black head, takes the recommended supplements  he will kill acne before it is born.

In fact any teenager should be proactive and think of supplying his body with abundant amounts of Coenzyme A, by taking these supplements.

Acne is caused by excess oil in the skin (also known as sebum).  This oil comes from sebum secretion by the sebaceous glands at the root of the hair follicles.  This oily build up occludes the pores in the skin causing blockage and infection.  The well known practice of "popping" the pimple forces the occluding plug to pop out of the pore, thereby allowing drainage of the sebaceous glands at the root of the hair follicle and providing temporary relief.

Left Image:  Note Sebum (pink) in this diagram of hair follicle with sebaceous glands and sebum (pink). Courtesy of Wikimedia Commons

Common Causes of Acne

Acne is a common adverse side effect of synthetic birth control pills which mimic testosterone.  Elevated testosterone levels in males and females are associated with increased oil production in the  skin resulting in acne.  A common genetic mutation called atypical CAH (congenital adrenal hyperplasia) causes increased testosterone in females resulting in acne.  PCOS (polycystic ovary syndrome) syndrome is associated with increased testosterone production and acne is common. 

Young males may suffer from acne merely because of abundant (and normal) testosterone production.  Below, we will make the case for a vitamin B5 deficiency as a cause for acne. 

What are the Acne Treatments?

Traditionally, acne is treated by the dermatologist with various topical cleansers, antibiotics and drugs such as Accutane.   Accutane's most commonly reported  adverse side effect is depression which can lead to suicide.

Vitamin B5 Treatment for Acne

In this article we will present to you information about Vitamin B5 (pantothenic acid) as a treatment for acne.  We will explain the role of Vitamin B5 in the metabolism of fats and oils, and how increasing the metabolism of oils will reduce oil accumulation in the skin, and thereby reduce or eliminate acne.  Both Accutane and Vitamin B5 work by different mechanisms.  Accutane works by shrinking the sebaceous glands at the root of the hair follicles.  However, Vitamin B5 works by reducing the oil production of the sebaceous glands.  This is done by increasing Coenzyme A (Co-A) which increases the metabolic breakdown of oils by normal activity of cell physiology.

Co-Enzyme A and Pantothenic Acid for Acne
 
Article by Lit-Hung Leung on Co-Enzyme A

I first became aware of the use of Vitamin B5 (also called pantothenic acid) as a treatment for acne from an article by Lit-Hung Leung (1997).  In this article, Dr Leung explains that acne can be reduced or eliminated with the use of Vitamin B5, also called pantothenic acid. 

Image left: Co Enzyme A and location of Pantothenic Acid in the CoEnzyme A molecule at the left side.

How does it work?

Pantothenic acid is a major component of Co Enzyme A (see diagram above).  CoA is used at the cellular level for fatty acid oxidation and in many other biochemical reactions in the cell.  Taking additional B5 increases the amount of Coenzyme A available for use in the cell.  The more Co-Enzyme A, the more fatty acids can be metabolized, which means they are oxidized or burned up as energy production.

CoEnzyme A is actually a Pantothenic Acid molecule attached to an ADP molecule (see diagram above, ADP=adenine triphosphate).  ADP is widely available throughout cellular biochemistry as the currency of energy in the cell.

What is Pantethine?

Pantethine is made of two Vitamin B5 molecules linked together with two sulfurs (S) in the center (see below diagram).

 

Above Image: Pantethine Courtesy of Wikimedia Commons Note two B5, Pantothenic Acid Molecules attached with the two sulfur molecules (S) in the center.

It is well known that the Beta Oxidation of Fatty Acids depends on CoA.   If there is a deficiency of Acetyl CoA in the body, oxidation of fatty acids will slow down, and the skin becomes oily resulting in acne.  Increasing the amount of Acetyl CoA available speeds up the metabolism of fatty acids which are then used for energy production.  Taking the vitamin B5, pantothenic acid is the easiest way to increase acetyl Co A and increase rate of fatty acid metabolism.



L-Carnitine Used as Booster

Obviously, the major difficulty with Dr Leung's Vitamin B5 protocol is the large amount of B5 required.  It would be advantageous to reduce the B5 dosage to a more reasonable level.  Considering the biochemical pathways involved, this would be possible with the addition of L-carnitine, which transports fatty acids across the mitochondrial membrane where they can be oxidized. 

Transport is Rate Limiting Step for Faty Acid Oxidation

According to the biochemisty of fatty acid oxidation, "Transport is RATE LIMITING STEP for oxidation of long chain fatty acids." (From USD Biochemisty Lecture)

See the diagram below which shows the importance of L-Carnitine in transporting the fatty acid (the Acyl Group is the fatty acid chain) into the mitochondrial matrix.

"Carnitine transports long-chain acyl groups from fatty acids into the mitochondrial matrix, so that they can be broken down through ß-oxidation to acetate to obtain usable energy via the citric acid cycle." (Quoted from Wikipedia). 







Article By : Dr.Jeffrey Dach MD Hollywood Florida


Our research:

We have found using Pantethine and Vitamin B5 together boosts the Coenzyme A levels better and also with less pills to take, bringing the Pantethine into the System. We hereby offer a natural alternative to
Roacutanne to clients and a product that is medically safe and have medical backing for use for even your young teenagers.